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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK9
All Species:
17.88
Human Site:
Y262
Identified Species:
26.22
UniProt:
P50750
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50750
NP_001252.1
372
42778
Y262
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001094502
352
40482
Y242
N
V
D
N
Y
E
L
Y
E
K
L
E
L
V
K
Dog
Lupus familis
XP_548446
534
59045
F424
N
V
D
K
Y
E
L
F
E
K
L
D
L
V
K
Cat
Felis silvestris
Mouse
Mus musculus
NP_570930
372
42743
F262
N
V
D
K
Y
E
L
F
E
K
L
E
L
V
K
Rat
Rattus norvegicus
Q641Z4
372
42743
F262
N
V
D
K
Y
E
L
F
E
K
L
E
L
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520593
314
36161
K214
L
D
L
P
R
G
Q
K
R
K
V
K
E
R
L
Chicken
Gallus gallus
Q5ZKN1
372
42784
Y262
N
V
D
K
Y
E
L
Y
Q
K
L
E
L
P
K
Frog
Xenopus laevis
Q4V862
376
43205
Y266
N
V
D
K
Y
E
L
Y
Q
K
L
E
L
P
K
Zebra Danio
Brachydanio rerio
NP_997756
393
45129
L283
G
V
D
K
K
Y
E
L
Y
Q
K
M
E
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477226
404
46768
Y294
G
V
E
E
L
E
L
Y
K
S
I
E
L
P
K
Honey Bee
Apis mellifera
XP_396015
382
43973
F268
G
V
E
N
L
E
L
F
N
K
M
D
L
P
K
Nematode Worm
Caenorhab. elegans
Q9TVL3
478
53575
W332
N
C
V
N
M
P
L
W
S
A
M
S
S
E
P
Sea Urchin
Strong. purpuratus
XP_798269
410
46418
S291
G
L
E
K
L
E
L
S
N
T
L
E
L
P
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LFT8
505
56711
F274
G
V
S
K
M
P
W
F
N
N
F
K
P
A
R
Baker's Yeast
Sacchar. cerevisiae
P23293
657
74221
A316
V
A
R
Y
L
P
G
A
E
L
T
T
T
N
Y
Red Bread Mold
Neurospora crassa
Q871M9
545
61347
G277
G
W
R
T
L
P
G
G
Q
A
F
S
S
K
P
Conservation
Percent
Protein Identity:
100
N.A.
92.4
68.5
N.A.
98.6
98.6
N.A.
77.9
93
89.3
85.5
N.A.
66
72.7
43.3
67.3
Protein Similarity:
100
N.A.
93.5
69.4
N.A.
99.7
99.7
N.A.
80.3
95.4
94.1
89.5
N.A.
75.9
83.2
56.4
75.8
P-Site Identity:
100
N.A.
100
80
N.A.
86.6
86.6
N.A.
6.6
80
80
13.3
N.A.
46.6
46.6
20
40
P-Site Similarity:
100
N.A.
100
93.3
N.A.
93.3
93.3
N.A.
20
86.6
86.6
26.6
N.A.
66.6
73.3
33.3
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
36
25.2
31.7
Protein Similarity:
N.A.
N.A.
N.A.
51
39.4
45.6
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
6.6
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
7
0
13
0
0
0
7
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
50
0
0
0
0
0
0
0
0
13
0
0
0
% D
% Glu:
0
0
19
7
0
63
7
0
38
0
0
50
13
7
0
% E
% Phe:
0
0
0
0
0
0
0
32
0
0
13
0
0
0
0
% F
% Gly:
38
0
0
0
0
7
13
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% I
% Lys:
0
0
0
50
7
0
0
7
7
57
7
13
0
7
63
% K
% Leu:
7
7
7
0
32
0
69
7
0
7
50
0
63
7
7
% L
% Met:
0
0
0
0
13
0
0
0
0
0
13
7
0
0
0
% M
% Asn:
50
0
0
25
0
0
0
0
19
7
0
0
0
7
0
% N
% Pro:
0
0
0
7
0
25
0
0
0
0
0
0
7
32
19
% P
% Gln:
0
0
0
0
0
0
7
0
19
7
0
0
0
0
0
% Q
% Arg:
0
0
13
0
7
0
0
0
7
0
0
0
0
7
7
% R
% Ser:
0
0
7
0
0
0
0
7
7
7
0
13
13
0
0
% S
% Thr:
0
0
0
7
0
0
0
0
0
7
7
7
7
0
0
% T
% Val:
7
69
7
0
0
0
0
0
0
0
7
0
0
32
0
% V
% Trp:
0
7
0
0
0
0
7
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
44
7
0
32
7
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _